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Proceedings Paper

An intrauterine ultrasound applicator for targeted delivery of thermal therapy in conjunction with HDR brachytherapy to the cervix
Author(s): Jeffery H. Wootton; Titania Juang; Jean Pouliot; I-Chow Joe Hsu; Chris J. Diederich
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Paper Abstract

An intracavitary hyperthermia applicator for targeted heat delivery to the cervix was developed based on a linear array of sectored tubular ultrasound transducers that provides truly 3-D heating control (angular and along the length). A central conduit can incorporate an HDR source for sequential or simultaneous delivery of heat and radiation. Hyperthermia treatment volumes were determined from brachytherapy treatment planning data and used as a basis for biothermal simulations analyzing the effects of device parameters, tissue properties, and catheter materials on heating patterns. Devices were then developed with 1-3 elements at 6.5-8 MHz with 90-180° sectors and a 15-35 mm heating length, housed within a 6-mm diameter water-cooled PET catheter. Directional heating from sectored transducers could extend lateral penetration of therapeutic heating (41°C) >2 cm while maintaining rectum and bladder temperatures within 12 mm below thermal damage thresholds. Imaging artifacts were evaluated with standard CT, cone beam CT, and MR images. MR thermal imaging was used to demonstrate shaping of heating profiles in axial and coronal slices with artifact <2 mm from the device. The impact of the high-Z applicator materials on the HDR dose distribution was assessed using a well-type ionization chamber and was found to be less than 6% attenuation, which can readily be accounted for with treatment planning software. The intrauterine ultrasound device has demonstrated potential for 3-D conformal heating of clinical tumors in the delivery of targeted hyperthermia in conjunction with brachytherapy to the cervix.

Paper Details

Date Published: 23 February 2009
PDF: 9 pages
Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810T (23 February 2009); doi: 10.1117/12.808343
Show Author Affiliations
Jeffery H. Wootton, Univ. of California, San Francisco (United States)
Univ. of California, Berkeley (United States)
Titania Juang, Univ. of California, San Francisco (United States)
Jean Pouliot, Univ. of California, San Francisco (United States)
I-Chow Joe Hsu, Univ. of California, San Francisco (United States)
Chris J. Diederich, Univ. of California, San Francisco (United States)
Univ. of California, Berkeley (United States)


Published in SPIE Proceedings Vol. 7181:
Energy-based Treatment of Tissue and Assessment V
Thomas P. Ryan, Editor(s)

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