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Proceedings Paper

Application of a multicompartment dynamical model to multimodal optical imaging for investigating individual cerebrovascular properties
Author(s): Michèle Desjardins; Louis Gagnon; Claudine Gauthier; Rick D. Hoge; Mathieu Dehaes; Laurence Desjardins-Crépeau; Louis Bherer; Frédéric Lesage
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Paper Abstract

Biophysical models of hemodynamics provide a tool for quantitative multimodal brain imaging by allowing a deeper understanding of the interplay between neural activity and blood oxygenation, volume and flow responses to stimuli. Multicompartment dynamical models that describe the dynamics and interactions of the vascular and metabolic components of evoked hemodynamic responses have been developed in the literature. In this work, multimodal data using near-infrared spectroscopy (NIRS) and diffuse correlation flowmetry (DCF) is used to estimate total baseline hemoglobin concentration (HBT0) in 7 adult subjects. A validation of the model estimate and investigation of the partial volume effect is done by comparing with time-resolved spectroscopy (TRS) measures of absolute HBT0. Simultaneous NIRS and DCF measurements during hypercapnia are then performed, but are found to be hardly reproducible. The results raise questions about the feasibility of an all-optical model-based estimation of individual vascular properties.

Paper Details

Date Published: 20 February 2009
PDF: 14 pages
Proc. SPIE 7171, Multimodal Biomedical Imaging IV, 717109 (20 February 2009); doi: 10.1117/12.808317
Show Author Affiliations
Michèle Desjardins, Ecole Polytechnique de Montréal (Canada)
Ctr. de recherche de l'Institut Univ. de gériatrie de Montréal (Canada)
Louis Gagnon, Ecole Polytechnique de Montréal (Canada)
Ctr. de recherche de l'Institut Univ. de gériatrie de Montréal (Canada)
Claudine Gauthier, Ctr. de recherche de l'Institut Univ. de gériatrie de Montréal (Canada)
Rick D. Hoge, Ctr. de recherche de l'Institut Univ. de gériatrie de Montréal (Canada)
Mathieu Dehaes, Ecole Polytechnique de Montréal (Canada)
Ctr. de recherche de l'Institut Univ. de gériatrie de Montréal (Canada)
Laurence Desjardins-Crépeau, Ctr. de recherche de l'Institut Univ. de gériatrie de Montréal (Canada)
Univ. du Québec à Montréal (Canada)
Louis Bherer, Ctr. de recherche de l'Institut Univ. de gériatrie de Montréal (Canada)
Univ. du Québec à Montréal (Canada)
Frédéric Lesage, Ecole Polytechnique de Montréal (Canada)
Ctr. de recherche de l'Institut Univ. de gériatrie de Montréal (Canada)


Published in SPIE Proceedings Vol. 7171:
Multimodal Biomedical Imaging IV
Fred S. Azar; Xavier Intes, Editor(s)

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