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Proceedings Paper

A hierarchical spatial prior approach for prostate image reconstruction in trans-rectal optical tomography
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Paper Abstract

An approach of hierarchically implementing the spatial prior information in trans-rectal optical tomography is introduced. Trans-rectal optical imaging of the prostate deals with photon propagation through the rectum wall, the peri-prostate tissue and the prostate. Reconstructing a lesion in the prostate is challenging due to the structural complexity as well as the optical heterogeneity. Incorporating spatial "hard" a priori information available from complementary imaging modalities such as trans-rectal ultrasound could in principle improve the accuracy of trans-rectal optical tomography reconstruction. However, the reconstruction is potentially subject to the local-minimum sensitivity if the values of all regional optical properties are to be initialized simultaneously. We propose a hierarchical spatial prior approach for trans-rectal optical tomography reconstruction. Instead of assigning the initial values to all sub-regions at once, a region is initially assumed homogenous, and the reconstructed optical properties are used as the initial guess for the region as a background when a sub-region is included in the next step. This approach translates to a 3-step iteration routine whereby the first step reconstructs the entire imaging volume as a single region, the second step uses these results as the initial guess of peri-prostate tissue to reconstruct the prostate and the rectum wall, and the third step assigns the updated results as the initial values of 3 existing regions to reconstruct a lesion inside the prostate. This approach, validated by simulation and applied to experimental measurements, is more reliable in global convergence, robust in imaging of single or multiple targets, and accurate for the recovering of optical properties.

Paper Details

Date Published: 20 February 2009
PDF: 12 pages
Proc. SPIE 7171, Multimodal Biomedical Imaging IV, 71710S (20 February 2009); doi: 10.1117/12.808208
Show Author Affiliations
Guan Xu, Oklahoma State Univ. (United States)
Charles F. Bunting, Oklahoma State Univ. (United States)
Hamid Dehghani, Univ. of Exeter (United Kingdom)
Daqing Piao, Oklahoma State Univ. (United States)


Published in SPIE Proceedings Vol. 7171:
Multimodal Biomedical Imaging IV
Fred S. Azar; Xavier Intes, Editor(s)

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