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Proceedings Paper

Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo
Author(s): M. A. Sirotkina; E. V. Zagaynova; M. V. Shirmanova; P. A. Agrba; V. A. Kamensky
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Paper Abstract

Dynamics of nanoparticles penetrating and accumulating in healthy (skin) and pathologically altered (tumor) tissue was investigated in vivo by the method of optical coherence tomography (OCT). Gold nanoshells having the size of 130/15 nm and titanium dioxide nanoparticles 40-100 nm in size were studied. Nanoparticles accumulation in biotissue was accompanied by the change of optical effects in OCT images. Continuous OCT monitoring of the process of nanoparticles penetration into skin showed that optical effects appeared 30 minutes after application of nanoparticles on the surface; maximal effect of nanoparticles accumulation in the skin was recorded in the observation period of 1.5-5 hours. Nanoparticles accumulation in neoplastic tissue at passive delivery was studied in vivo. Accumulation maximum was 4-6 hours after intravenous introduction. The transmission electron microscopy technique confirmed accumulation of nanoparticles in biotissues.

Paper Details

Date Published: 16 February 2009
PDF: 7 pages
Proc. SPIE 7188, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI, 71880L (16 February 2009); doi: 10.1117/12.808098
Show Author Affiliations
M. A. Sirotkina, Nizhny Novgorod State Medical Academy (Russian Federation)
E. V. Zagaynova, Nizhny Novgorod State Medical Academy (Russian Federation)
M. V. Shirmanova, Nizhny Novgorod State Medical Academy (Russian Federation)
N.I. Lobachevsky State Univ. of Nizhny Novgorod (Russian Federation)
P. A. Agrba, Institute of Applied Physics (Russian Federation)
V. A. Kamensky, Institute of Applied Physics (Russian Federation)


Published in SPIE Proceedings Vol. 7188:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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