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Proceedings Paper

Optimizing Fourier-domain angle resolved low coherence interferometry for clinical use
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Paper Abstract

Methods for the optimization of a/LCI for clinical use are presented. First, the use of the T-matrix light scattering model to simulate scattering from spheroidal particles is presented as a more appropriate simulation of cell nuclei scattering than the previously used Mie theory. In addition, the use of a broadband light source with a bandwidth greater than 50nm similar to those utilized in OCT applications is demonstrated. Accurate sizing of scatterers in tissue phantoms containing stretched and unstretched polystyrene microspheres along with measurements of unstretched polystyrene microspheres in solution are presented, demonstrating advances in system performance and design. In addition, preliminary human in vivo esophageal tissue data are presented.

Paper Details

Date Published: 24 February 2009
PDF: 11 pages
Proc. SPIE 7187, Biomedical Applications of Light Scattering III, 71870W (24 February 2009); doi: 10.1117/12.808021
Show Author Affiliations
Neil G. Terry, Duke Univ. (United States)
Yizheng Zhu, Duke Univ. (United States)
Matthew Rinehart, Duke Univ. (United States)
Adam Wax, Duke Univ. (United States)


Published in SPIE Proceedings Vol. 7187:
Biomedical Applications of Light Scattering III
Adam Wax; Vadim Backman, Editor(s)

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