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Proceedings Paper

Light scattering by ellipsoidal particles and Fourier analysis in the frequency domain
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Paper Abstract

The study of biological tissue using white light spectroscopy has the potential to be an effective, fast, and inexpensive method for the detection of size changes in cell nuclei. The relationship between the spherical scatterer size and the number of oscillation peaks in the optical spectrum (intensity of scattered light versus wavelength) has been observed by many researchers. To this point, there was not a detailed theoretical model describing this dependence for elliptical particles, a common shape of cell nuclei at lower tissue layers. In this paper, we report a theoretical model, valid for both spheres and ellipsoids, detailing the scattering intensity as a function of the wavelength and the scatterer's diameter. Supporting this theory, we experimentally test mixtures of scatterers of different sizes and provide density analysis.

Paper Details

Date Published: 24 February 2009
PDF: 11 pages
Proc. SPIE 7187, Biomedical Applications of Light Scattering III, 718719 (24 February 2009); doi: 10.1117/12.807938
Show Author Affiliations
Kaloyan A. Popov, Drexel Univ. (United States)
Timothy P. Kurzweg, Drexel Univ. (United States)

Published in SPIE Proceedings Vol. 7187:
Biomedical Applications of Light Scattering III
Adam Wax; Vadim Backman, Editor(s)

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