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Proceedings Paper

Melanoma thickness measurement in two-layer tissue phantoms using pulsed photothermal radiometry (PPTR)
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Paper Abstract

Melanoma is a malignant tumor of melanocytes which are found predominantly in skin. Melanoma is one of the rarer types of skin cancer but causes the majority of skin cancer related deaths. The staging of malignant melanoma using Breslow thickness is important because of the relationship to survival rate after five years. Pulsed photothermal radiometry (PPTR) is based on the time-resolved acquisition of infrared (IR) emission from a sample after pulsed laser exposure. PPTR can be used to investigate the relationship between melanoma thickness and detected radiometric temperature using two-layer tissue phantoms. We used a Monte Carlo simulation to mimic light transport in melanoma and employed a three-dimensional heat transfer model to obtain simulated radiometric temperature increase and, in comparison, we also conducted PPTR experiments to confirm our simulation results. Simulation and experimental results show similar trends: thicker absorbing layers corresponding to deeper lesions produce slower radiometric temperature decays. A quantitative relationship exists between PPTR radiometric temperature decay time and thickness of the absorbing layer in tissue phantoms.

Paper Details

Date Published: 12 February 2009
PDF: 9 pages
Proc. SPIE 7175, Optical Interactions with Tissue and Cells XX, 71750L (12 February 2009); doi: 10.1117/12.807931
Show Author Affiliations
Tianyi Wang, The Univ. of Texas at Austin (United States)
Jinze Qiu, The Univ. of Texas at Austin (United States)
Amit Paranjape, The Univ. of Texas at Austin (United States)
Thomas E. Milner, The Univ. of Texas at Austin (United States)

Published in SPIE Proceedings Vol. 7175:
Optical Interactions with Tissue and Cells XX
Steven L. Jacques; E. Duco Jansen; William P. Roach, Editor(s)

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