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Proceedings Paper

Spatial and temporal effects in speckle perfusion measurement
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Paper Abstract

Laser speckle contrast techniques have been increasingly applied to dermal perfusion measurements over the past few years. The interpretation of laser speckle contrast and its conversion to a physiologically-defined perfusion parameter related to that found from Doppler measurements is becoming clearer. Speckle contrast-based techniques provide both quantified perfusion images and a time-series record of perfusion. We use the image resolution available in speckle measurements to investigate spatial resolution which can be expected in tissue; in particular to reconcile speckle measurements with the large point-to-point variations reported from fibre Doppler probes. In vitro models show the extent of spatial blurring likely to be encountered in speckle measurements at different depths. Perfusion responses related to vascular challenges could have medical relevance. We find a small pulse-related signal in dermal speckle data. By identifying pulses in a temporal record using a matched filter, we find statistical average pulse shapes for several different subjects, allowing comparison of pulsatile flow profiles between them. The profiles measured by this technique are repeatable on the same subject, and vary between subjects. At some body sites, notably near arterioles, the response obviously relates to gross tissue motion, but at others the signature is of dermal origin. It is not yet clear whether it relates to actual capillary flow variation or distortion of the scattering tissue in response to changes in the driving pressure.

Paper Details

Date Published: 12 February 2009
PDF: 12 pages
Proc. SPIE 7176, Dynamics and Fluctuations in Biomedical Photonics VI, 717604 (12 February 2009); doi: 10.1117/12.807901
Show Author Affiliations
O. B. Thompson, Industrial Research Ltd. (New Zealand)
M. K. Andrews, Industrial Research Ltd. (New Zealand)

Published in SPIE Proceedings Vol. 7176:
Dynamics and Fluctuations in Biomedical Photonics VI
Valery Viktorovich Tuchin; Lihong V. Wang; Donald D. Duncan, Editor(s)

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