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Proceedings Paper

A continuous-wave mode elliptic-region-based DOT methodology based on BEM-diffusion modeling
Author(s): Pingqiao Ruan; Yanfang Liu; Feng Gao; Huijuan Zhao; Meng Jin
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Paper Abstract

Acquisition of the optical structures within a biological body is critical to all the diffuse light imaging modalities, such as diffuse optical tomography (DOT) and fluorescence molecular tomography (FMT). On an assumption of the optical homogeneity within the organs, it can be cast as a shape-based DOT issue, which aims at simultaneously reconstructing the boundary-describing parameters and optical properties of the disjoint domains of distinct tissue types. As the first step to the solution of this issue, we propose here a continuous-wave mode, elliptic-region-based DOT scheme. The methodology employs the boundary-element-method (BEM) solution to the diffusion equation as the forward model, and solves a nonlinear inverse issue that seeks an optimal boundary configuration as well as the optical properties to minimize the residual norm between measured and predicted data. The proposed scheme is validated using simulated data for a cylindrical geometry embedding two absorption- and scattering-contrasting ellipses at different noise levels.

Paper Details

Date Published: 12 February 2009
PDF: 9 pages
Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741S (12 February 2009); doi: 10.1117/12.807900
Show Author Affiliations
Pingqiao Ruan, Tianjin Univ. (China)
Yanfang Liu, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Meng Jin, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 7174:
Optical Tomography and Spectroscopy of Tissue VIII
Bruce J. Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva M. Sevick-Muraca; Robert R. Alfano, Editor(s)

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