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Proceedings Paper

Optical coherence tomography and Raman spectroscopy of the retina
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Paper Abstract

Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combining these imaging modalities. We present an ex vivo OCT microscope combined with Raman spectroscopy capable of collecting morphological and molecular information about a sample simultaneously. The combined instrument will be used to investigate remaining technical challenges to combine these imaging modalities, such as the laser power levels needed to achieve a Raman signal above the noise level without damaging the sample.

Paper Details

Date Published: 20 February 2009
PDF: 8 pages
Proc. SPIE 7171, Multimodal Biomedical Imaging IV, 71710O (20 February 2009); doi: 10.1117/12.807885
Show Author Affiliations
Julia W. Evans, Lawrence Livermore National Lab. (United States)
Vision Science and Advanced Retinal Imaging Lab., Univ. of California, Davis (United States)
NSF Ctr. for Biophotonics Science and Technology, Univ. of California, Davis (United States)
Robert J. Zawadzki, Vision Science and Advanced Retinal Imaging Lab., Univ. of California, Davis (United States)
Rui Liu, NSF Ctr. for Biophotonics Science and Technology, Univ. of California, Davis (United States)
James W. Chan, Lawrence Livermore National Lab. (United States)
NSF Ctr. for Biophotonics Science and Technology, Univ. of California, Davis (United States)
Stephen M. Lane, NSF Ctr. for Biophotonics Science and Technology, Univ. of California, Davis (United States)
John S. Werner, Vision Science and Advanced Retinal Imaging Lab., Univ. of California, Dav (United States)


Published in SPIE Proceedings Vol. 7171:
Multimodal Biomedical Imaging IV
Fred S. Azar; Xavier Intes, Editor(s)

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