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Proceedings Paper

Bioluminescence tomography using spectral techniques
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Paper Abstract

Spectrally-resolved BioLuminescence optical Tomography (BLT) aims to reconstruct tomographic images of Luciferase activity within a volume using spectrally resolved emission data from internal bioluminescence sources. Uniqueness as associated with non-spectrally resolved intensity-based BioLuminescence Tomography is an established drawback and it is also demonstrated that without the use of a non-negative constraint inverse algorithm the solution is inaccurate. Reconstructed images of bioluminescence are presented showing that the location of the internal bioluminescence source can be obtained with 0.5 mm accuracy. The concept of the reciprocity approach for image reconstruction is outlined providing a dramatic improvement in computational time without loss to image accuracy.

Paper Details

Date Published: 20 February 2009
PDF: 10 pages
Proc. SPIE 7171, Multimodal Biomedical Imaging IV, 717104 (20 February 2009); doi: 10.1117/12.807738
Show Author Affiliations
Hamid Dehghani, Univ. of Exeter (United Kingdom)
Scott C. Davis, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 7171:
Multimodal Biomedical Imaging IV
Fred S. Azar; Xavier Intes, Editor(s)

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