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Proceedings Paper

High resolution optoelectronic retinal prosthesis
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Paper Abstract

Electronic retinal prostheses seek to restore sight in patients with retinal degeneration by delivering pulsed electric currents to retinal neurons via an array of microelectrodes. Most implants use inductive or optical transmission of information and power to an intraocular receiver, with decoded signals subsequently distributed to retinal electrodes through an intraocular cable. Surgical complexity could be minimized by an "integrated" prosthesis, in which both power and data are delivered directly to the stimulating array without any discrete components or cables. We present here an integrated retinal prosthesis system based on a photodiode array implant. Video frames are processed and imaged onto the retinal implant by a video goggle projection system operating at near-infrared wavelengths (~ 900 nm). Photodiodes convert light into pulsed electric current, with charge injection maximized by specially optimized series photodiode circuits. Prostheses of three different pixel densities (16 pix/mm2, 64 pix/mm2, and 256 pix/mm2) have been designed, simulated, and prototyped. Retinal tissue response to subretinal implants made of various materials has been investigated in RCS rats. The resulting prosthesis can provide sufficient charge injection for high resolution retinal stimulation without the need for implantation of any bulky discrete elements such as coils or tethers. In addition, since every pixel functions independently, pixel arrays may be placed separately in the subretinal space, providing visual stimulation to a larger field of view.

Paper Details

Date Published: 18 February 2009
PDF: 11 pages
Proc. SPIE 7163, Ophthalmic Technologies XIX, 71631B (18 February 2009); doi: 10.1117/12.807668
Show Author Affiliations
Jim Loudin, Stanford Univ. (United States)
Rostam Dinyari, Stanford Univ. (United States)
Phil Huie, Stanford Univ. (United States)
Alex Butterwick, Stanford Univ. (United States)
Peter Peumans, Stanford Univ. (United States)
Daniel Palanker, Stanford Univ. (United States)

Published in SPIE Proceedings Vol. 7163:
Ophthalmic Technologies XIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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