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Proceedings Paper

Design and development of multifunctional contrast agents for photoacoustic imaging
Author(s): Kimberly Homan; Sobeyda Gomez; Heidi Gensler; Jignesh Shah; L. Brannon-Peppas; Stanislav Emelianov
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Paper Abstract

We have developed a multifunctional nanoagent, termed the combined imaging and therapy nanocage system (CIT-NS). This nanosystem platform consists of a poly(lactic-co-glycolic) acid polymer core and outer silver cage network. The inner core of CIT-NS is capable of carrying drugs, such as the chemotherapeutic agent doxorubicin, or imaging contrast agents, such as dyes or fluorescent compounds. The outer silver cage is specifically designed to enhance contrast in photoacoustic imaging, i.e., acoustic imaging of optical absorption. In this paper, methods to create the CIT-NS are described. Initial characterization indicates that the developed CIT-NS will significantly increase contrast in photoacoustic imaging while retaining the potential to deliver large payloads of drug simultaneously. Therefore, the CITNS may enable multi-modal imaging approaches or simultaneous imaging and therapy strategies to improve treatment and detection of cancer and other pathologies.

Paper Details

Date Published: 21 February 2009
PDF: 7 pages
Proc. SPIE 7190, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications, 71900I (21 February 2009); doi: 10.1117/12.807522
Show Author Affiliations
Kimberly Homan, The Univ. of Texas at Austin (United States)
Sobeyda Gomez, The Univ. of Texas at Austin (United States)
Heidi Gensler, The Univ. of Texas at Austin (United States)
Jignesh Shah, The Univ. of Texas at Austin (United States)
L. Brannon-Peppas, Appian Labs LLC (United States)
Stanislav Emelianov, The Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 7190:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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