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Proceedings Paper

Combined ultrasound and photoacoustic imaging of pancreatic cancer using nanocage contrast agents
Author(s): Kimberly Homan; Jignesh Shah; Sobeyda Gomez; Heidi Gensler; Andrei Karpiouk; L. Brannon-Peppas; Stanislav Emelianov
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Paper Abstract

A new metallodielectric nanoparticle consisting of a silica core and silver outer cage was developed for the purpose of enhancing photoacoustic imaging contrast in pancreatic tissue. These nanocages were injected into an ex vivo porcine pancreas and imaged using a combined photoacoustic and ultrasound (PAUS) assembly. This custom-designed PAUS assembly delivered 800 nm light through a fiber optical light delivery system integrated with 128 element linear array transducer operating at 7.5 MHz center frequency. Imaging results prove that the nanocage contrast agents have the ability to enhance photoacoustic imaging contrast. Furthermore, the value of the combined PAUS imaging modality was demonstrated as the location of nanocages against background native tissue was evident. Future applications of these nanocage contrast agents could include targeting them to pancreatic cancer for enhancement of photoacoustic imaging for diagnosis and therapy.

Paper Details

Date Published: 12 February 2009
PDF: 6 pages
Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71771M (12 February 2009); doi: 10.1117/12.807520
Show Author Affiliations
Kimberly Homan, The Univ. of Texas at Austin (United States)
Jignesh Shah, The Univ. of Texas at Austin (United States)
Sobeyda Gomez, The Univ. of Texas at Austin (United States)
Heidi Gensler, The Univ. of Texas at Austin (United States)
Andrei Karpiouk, The Univ. of Texas at Austin (United States)
L. Brannon-Peppas, The Univ. of Texas at Austin (United States)
Stanislav Emelianov, The Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 7177:
Photons Plus Ultrasound: Imaging and Sensing 2009
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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