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Proceedings Paper

A micro hemoglobin-A1c immunosensor based on FET and electrochemical growth of gold nanoparticles
Author(s): Lan Qu; Chao Bian; Jizhou Sun; Jinghong Han; Shanhong Xia
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Paper Abstract

A micro potentiometric hemoglobin-A1c (HbA1c) immunosensor based on field-effect transistor (FET) and electrochemical growth of gold nanoparticles (AuNPs) in polypyrrole (PPy) film is reported. Integrated ion-sensitive field-effect transistors (ISFETs) chips containing two ISFETs, two reference FETs (REFET) and the signal read-out circuits were fabricated. Micro electrodes of the sensor were fabricated by MEMS techniques and electrochemical method, both compatible with electrode miniaturization. The simple and direct procedure to form PPy-AuNPs composite film enhances the sensitivity of the micro sensor. Electrochemical characterization and morphology study by scanning electron microscopy (SEM) confirm the presence of AuNPs in PPy. Simple, rapid and precise differential measurement of HbA1c is achieved. HbA1c in the concentration ranges of 2-20 ng/ml and 4-15 µg/ml can be detected by this sensor with a response time less than 1 min, which meets the needs of clinical detection of HbA1c. The miniaturized electrodes and integrated ISFET chip have the potential to be integrated and to achieve system on chip (SOC).

Paper Details

Date Published: 3 February 2009
PDF: 7 pages
Proc. SPIE 7159, 2008 International Conference on Optical Instruments and Technology: MEMS/NEMS Technology and Applications, 715908 (3 February 2009); doi: 10.1117/12.807112
Show Author Affiliations
Lan Qu, Institute of Electronics (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Chao Bian, Institute of Electronics (China)
Jizhou Sun, Institute of Electronics (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Jinghong Han, Institute of Electronics (China)
Shanhong Xia, Institute of Electronics (China)


Published in SPIE Proceedings Vol. 7159:
2008 International Conference on Optical Instruments and Technology: MEMS/NEMS Technology and Applications

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