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Proceedings Paper

Dynamic properties of different kinds of nanoparticles in mouse model after intravenous administration
Author(s): Yueqing Gu; Jian Zhang; Haiyan Chen; Zhiyu Qian
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Paper Abstract

Nanoparticles have a promising application prospect in biomedical field. The study of their dynamic characteristics including in vivo distribution and clearance has the most important significance on their biological application. In this paper, bio-distribution and clearance of solid and colloid nanoparticles with different size in mouse model was intensively studied in vivo by using near infrared optical imaging technique. Here, nanohydrogels were synthesized by precipitation polymerization method and the size of the nanohydrogel could be arbitrarily manipulated according to different surfactant concentration. Near infrared fluorescence dye were entrapped into their inner core for in vivo studies. Meanwhile, the size of CdHgTe/SiO2 solid nanoparticles could be controlled by the thickness of SiO2 coated on the surface of CdHgTe. The results from the near infrared imaging showed that nanohydrogels with different size have the similar tissue distribution but CdHgTe/SiO2 nanoparticles in different size have a size-dependent organ specification. These results provided an important reference for the design of targeted drug delivery systems and their biomedical applications.

Paper Details

Date Published: 21 February 2009
PDF: 9 pages
Proc. SPIE 7190, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications, 71900F (21 February 2009); doi: 10.1117/12.807028
Show Author Affiliations
Yueqing Gu, China Pharmaceutical Univ. (China)
Jian Zhang, China Pharmaceutical Univ. (China)
Haiyan Chen, China Pharmaceutical Univ. (China)
Zhiyu Qian, Nanjing Univ. of Aeronautics and Astronautics (China)


Published in SPIE Proceedings Vol. 7190:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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