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Proceedings Paper

High-efficiency microarray of 3-D carbon MEMS electrodes for pathogen detection systems
Author(s): Sam Kassegne; Berhanu Wondimu; Mohammad Majzoub; Jiae Shin
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Paper Abstract

Molecular diagnostic applications for pathogen detections require the ability to separate pathogens such as bacteria, viruses, etc., from a biological sample of blood or saliva. Over the past several years, conventional two-dimensional active microarrays have been used with success for the manipulation of biomolecules including DNA. However, they have a major drawback of inability to process relatively 'largevolume' samples useful in infectious disease diagnostics applications. This paper presents an active microarray of three-dimensional carbon electrodes that exploits electrokinetic forces for transport, accumulation, and hybridization of charged bio-molecules with an added advantage of large volume capability. Tall 3-dimensional carbon microelectrode posts are fabricated using C-MEMS (Carbon MEMS) technology that is emerging as a very exciting research area since carbon has fascinating physical, chemical, mechanical and electrical properties in addition to its low cost. The chip fabricated using CMEMS technology is packaged and its efficiency of separation and accumulation of charged particle established by manipulating negatively charged polycarboxylate 2 μm beads in 50 mM histidine buffer.

Paper Details

Date Published: 17 November 2008
PDF: 6 pages
Proc. SPIE 7266, Optomechatronic Technologies 2008, 726615 (17 November 2008); doi: 10.1117/12.806624
Show Author Affiliations
Sam Kassegne, San Diego State Univ. (United States)
Berhanu Wondimu, San Diego State Univ. (United States)
Mohammad Majzoub, San Diego State Univ. (United States)
Jiae Shin, San Diego State Univ. (United States)

Published in SPIE Proceedings Vol. 7266:
Optomechatronic Technologies 2008
John T. Wen; Dalibor Hodko; Yukitoshi Otani; Jonathan Kofman; Okyay Kaynak, Editor(s)

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