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Proceedings Paper

Improvement of up-converting phosphor technology-based biosensor
Author(s): Chengke Xie; Lihua Huang; Youbao Zhang; Xiaoxian Guo; Jianfeng Qu; Huijie Huang
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Paper Abstract

A novel biosensor based on up-converting phosphor technology (UPT) was developed several years ago. It is a kind of optical biosensor using up-converting phosphor (UCP) particles as the biological marker. From then on, some improvements have been made for this UPT-based biosensor. The primary aspects of the improvement lie in the control system. On one hand, the hardware of the control system has been optimized, including replacing two single chip microcomputers (SCM) with only one, the optimal design of the keyboard interface circuit and the liquid crystal module (LCM) control circuit et al.. These result in lower power consumption and higher reliability. On the other hand, a novel signal processing algorithm is proposed in this paper, which can improve the automation and operating simplicity of the UPT-based biosensor. It has proved to have high sensitivity (~ng/ml), high stability and good repeatability (CV<5%), which is better than the former system. It can meet the need of some various applications such as rapid immunoassay, chemical and biological detection and so on.

Paper Details

Date Published: 28 January 2009
PDF: 8 pages
Proc. SPIE 7156, 2008 International Conference on Optical Instruments and Technology: Optical Systems and Optoelectronic Instruments, 71561H (28 January 2009); doi: 10.1117/12.805654
Show Author Affiliations
Chengke Xie, Shanghai Institute of Optics and Fine Mechanics (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Lihua Huang, Shanghai Institute of Optics and Fine Mechanics (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Youbao Zhang, Shanghai Institute of Optics and Fine Mechanics (China)
Xiaoxian Guo, Shanghai Institute of Optics and Fine Mechanics (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Jianfeng Qu, Shanghai Institute of Optics and Fine Mechanics (China)
Huijie Huang, Shanghai Institute of Optics and Fine Mechanics (China)


Published in SPIE Proceedings Vol. 7156:
2008 International Conference on Optical Instruments and Technology: Optical Systems and Optoelectronic Instruments

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