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Proceedings Paper

Influence of vesicle size distribution on level and selectivity of accumulation of liposomal photosensitizer Tiosens in tumor
Author(s): Gennady A. Meerovich; Igor G. Meerovich; Daria G. Gurevich; Sergey I. Vorobyov; Vyacheslav G. Pevgov; Zoya S. Smirnova; Natalia A. Oborotova; Evgeny A. Lukyanets; Victor B. Loschenov; Anatoly Yu. Baryshnikov
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Paper Abstract

The work was performed to estimate the influence of liposomal size distribution on the level and selectivity of accumulation of photosensitizer of near-IR spectral range Tiosens (liposomal form of aluminium hydroxide phenylthiophthalocyanine) in tumor. Tiosens liposome dispersions were prepared using classic Bangham procedure. Particle size was reduced and unified using Avanti Mini-Extruder equipped with Nucleopore membranes and high-pressure homogenizer Donor-1. Liposomal size distribution was determined by means of laser correlation spectroscopy. Dynamics and selectivity of Tiosens accumulation in Erlich tumor were measured in vivo using fluorescence spectroscopy. It was shown that level and selectivity of accumulation of liposome-encapsulated drug is determined mostly by content of small-sized fractions, while fractions of larger size are quickly cleared from blood by RES and not contribute in photosensitizer accumulation.

Paper Details

Date Published: 5 June 2008
PDF: 6 pages
Proc. SPIE 7022, Advanced Laser Technologies 2007, 702210 (5 June 2008); doi: 10.1117/12.804091
Show Author Affiliations
Gennady A. Meerovich, General Physics Institute (Russia)
Igor G. Meerovich, N.N. Blokhin Russian Cancer Research Ctr. (Russia)
Daria G. Gurevich, N.N. Blokhin Russian Cancer Research Ctr. (Russia)
I.M. Sechenov Moscow Medical Academy (Russia)
Sergey I. Vorobyov, M.V. Lomonsov Moscow State Academy of Fine Chemical Technology (Russia)
Vyacheslav G. Pevgov, M.V. Chrunitchev State Cosmonautic Research and Production Ctr. (Russia)
Zoya S. Smirnova, N.N. Blokhin Russian Cancer Research Ctr. (Russia)
Natalia A. Oborotova, N.N. Blokhin Russian Cancer Research Ctr. (Russia)
Evgeny A. Lukyanets, State Scientific Ctr. NIOPIK (Russia)
Victor B. Loschenov, General Physics Institute (Russia)
Anatoly Yu. Baryshnikov, N.N. Blokhin Russian Cancer Research Ctr. (Russia)

Published in SPIE Proceedings Vol. 7022:
Advanced Laser Technologies 2007

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