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Proceedings Paper

Time gating in glucose sensing with ultrashort pulses
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Paper Abstract

The feasibility of the time-of-flight (TOF) technique application at the wavelength of 820 nm for the sensing the changes in optical properties of multilayered scattering medium is considered. The TOF signals from a 3-layer biotissue phantom consisting of two skin layers and a blood layer between them are obtained by using the Monte Carlo method for various values of glucose content. Glucose level variations in the physiological range of concentrations are supposed to induce changes in the optical properties of the blood-like layer and the bottom skin-like layer of the considered 3-layer phantom. Different characteristics of the obtained TOF signal are analyzed. Relative changes in the signals induced by the glucose level variations are analyzed for different source-detector separations. It is shown that the maximal relative change of the pulse energy corresponding to the glucose concentration change from 0 to 500 mg/dl is about 7%; however, the application of the time gating technique allows to increase this sensitivity up to 12 %. The sensitivity maps allowing to determin the optimal position and size of the time gate are obtained for five values of the source-detector separation.

Paper Details

Date Published: 5 June 2008
PDF: 7 pages
Proc. SPIE 7022, Advanced Laser Technologies 2007, 70220X (5 June 2008); doi: 10.1117/12.804085
Show Author Affiliations
Alexander V. Bykov, M.V. Lomonosov Moscow State Univ. (Russia)
Univ. of Oulu (Finland)
Mikhail Yu. Kirillin, Univ. of Oulu (Finland)
Alexander V. Priezzhev, M.V. Lomonosov Moscow State Univ. (Russia)
Risto Myllyla, Univ. of Oulu (Finland)

Published in SPIE Proceedings Vol. 7022:
Advanced Laser Technologies 2007

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