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Proceedings Paper

Near-infrared light as a possible treatment option for Parkinson's disease and laser eye injury
Author(s): Kristina DeSmet; Ellen Buchmann; Michele Henry; Margaret Wong-Riley; Janis Eells; Jim VerHoeve; Harry Whelan
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Paper Abstract

Studies in our laboratory demonstrate that the action spectrum for stimulation of cytochrome oxidase activity and cellular ATP parallels the near-infrared absorption spectrum of cytochrome oxidase and that 660-680 nm irradiation upregulates cytochrome oxidase activity in cultured neurons. Treatment with nearinfrared light augments cellular energy production and neuronal viability following mitochondrial injury linking the actions of red to near-infrared light on mitochondrial metabolism in vitro and cell injury in vivo. NIR light treatment represents an innovative therapeutic approach for disease processes in which mitochondrial dysfunction is postulated to play a role including Parkinson's disease, laser eye injury and Age-related macular degeneration.

Paper Details

Date Published: 18 February 2009
PDF: 10 pages
Proc. SPIE 7165, Mechanisms for Low-Light Therapy IV, 716503 (18 February 2009); doi: 10.1117/12.803964
Show Author Affiliations
Kristina DeSmet, Univ. of Wisconsin, Milwaukee (United States)
Ellen Buchmann, Medical College of Wisconsin (United States)
Michele Henry, Medical College of Wisconsin (United States)
Margaret Wong-Riley, Medical College of Wisconsin (United States)
Janis Eells, Univ. of Wisconsin, Milwaukee (United States)
Jim VerHoeve, Univ. of Wisconsin, Madison (United States)
Harry Whelan, Medical College of Wisconsin (United States)


Published in SPIE Proceedings Vol. 7165:
Mechanisms for Low-Light Therapy IV
Michael R. Hamblin; Ronald W. Waynant; Juanita Anders, Editor(s)

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