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Proceedings Paper

New efficient near-IR photosensitizer based on bacteriochlorin p N-methoxycycloimide oxyme methyl ester
Author(s): Igor G. Meerovich; Mikhail A. Grin; Alexander G. Tsyprovskiy; Gennady A. Meerovich; Natalia A. Oborotova; Victor B. Loschenov; Anatoly Yu. Baryshnikov; Andrey F. Mironov
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Paper Abstract

This work is devoted to investigation of new photosensitizer Bacteriochlorin p N-methoxycycloimide oxyme methyl ester (BchlpOx-NOMe). Investigations of photosensitizer in vivo and experimental PDT were performed on animals bearing intramuscularly inoculated Erlich tumor and B16 melanoma. Characteristic absorption maximum of BchlpOx-NOMe around 795 nm is within the range of minimum intrinsic absorption of biological tissue. Dynamics and selectivity of sensitizer accumulation in tumor and normal tissue were estimated from spectra of absorption of sensitized tissue in vivo. The investigation has shown that the optimum time range to start PDT irradiation of tumor is 10-30 min after administration. Photosensitizer has shown high photodynamic efficiency of relatively large tumors, including high PDT efficiency in preliminary experiments with BDF1 mice bearing B16 melanoma, causing tumor growth inhibition more than 90% and prolongation of lifespan of tumor-bearing animals more than 60%.

Paper Details

Date Published: 5 June 2008
PDF: 7 pages
Proc. SPIE 7022, Advanced Laser Technologies 2007, 702204 (5 June 2008); doi: 10.1117/12.803904
Show Author Affiliations
Igor G. Meerovich, N.N. Blokhin Russian Cancer Research Ctr. (Russia)
Mikhail A. Grin, M.V. Lomonosov Moscow State Academy of Fine Chemical Technology (Russia)
Alexander G. Tsyprovskiy, M.V. Lomonosov Moscow State Academy of Fine Chemical Technology (Russia)
Gennady A. Meerovich, General Physics Institute (Russia)
Natalia A. Oborotova, N.N. Blokhin Russian Cancer Research Ctr. (Russia)
Victor B. Loschenov, General Physics Institute (Russia)
Anatoly Yu. Baryshnikov, N.N. Blokhin Russian Cancer Research Ctr. (Russia)
Andrey F. Mironov, M.V. Lomonosov Moscow State Academy of Fine Chemical Technology (Russia)


Published in SPIE Proceedings Vol. 7022:
Advanced Laser Technologies 2007

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