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Proceedings Paper

Novel optical sensors for detection of toxins, viruses, and bacteria
Author(s): Gregory D. Emmerson; Ian J. G. Sparrow; Devaki Bhatta; Jean E. SohnaSohna
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Paper Abstract

A novel optical sensor system for rapid, sensitive and robust biological detection is presented. Sensor elements based on integrated optical circuits confine all optical signals into a planar format, resulting in a small, low-cost and mechanically stable refractive index sensor, without any external bulk optics. Consequently, the sensor elements are able to operate in real-world environments, resilient to vibration and temperature changes, whilst maintaining refractive index resolution of 10-6. Oxide surfaces on the sensor are ideal for protein attachment and have a long lifetime in buffer solutions (>100hrs). Real-time, label-free detection of biological agents has been demonstrated using antibodies attached to the sensor surface. The sensor design results in a large penetration depth of the sensing light, up to 1μm into the sample liquid, conferring the ability to detect various classes of biological targets, spanning toxins, viruses and bacteria. Each sensing element utilizes parallel multiple wavelength data to provide additional information at the point of measurement, resulting in on-chip temperature and strain referencing, focused towards increased accuracy and reduction of false alarms. The large size range of biological detection, coupled with the long lifetime of the sensors makes the system ideally suited to applications ranging from medical diagnostics to confirmatory detectors for homeland security

Paper Details

Date Published: 2 October 2008
PDF: 10 pages
Proc. SPIE 7116, Optically Based Biological and Chemical Detection for Defence IV, 711603 (2 October 2008); doi: 10.1117/12.800324
Show Author Affiliations
Gregory D. Emmerson, Stratophase Ltd. (United Kingdom)
Ian J. G. Sparrow, Stratophase Ltd. (United Kingdom)
Devaki Bhatta, Stratophase Ltd. (United Kingdom)
Jean E. SohnaSohna, Stratophase Ltd. (United Kingdom)

Published in SPIE Proceedings Vol. 7116:
Optically Based Biological and Chemical Detection for Defence IV
John C. Carrano; Arturas Zukauskas, Editor(s)

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