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Proceedings Paper

Wireless integrated microsystems for monitoring brain chemical and electrical activity
Author(s): Masoud Roham; Paul A. Garris; Pedram Mohseni
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Paper Abstract

A 16-channel chip for wireless in vivo recording of chemical and electrical neural activity is described. The 7.83-mm2 IC is fabricated using a 0.5-μm CMOS process and incorporates a 71-μW, 3rd-order, reconfigurable, ΔΣ modulator per channel, achieving an input-referred noise of 4.69 μVrms in 4-kHz BW and 94.1 pArms in 5-kHz BW for electrical and fast-scan voltammetric chemical neurosensing, respectively. The chip has been externally interfaced with carbon-fiber microelectrodes implanted acutely in the caudate-putamen of an anesthetized rat, and, for the first time, extracellular levels of dopamine elicited by electrical stimulation of the medial forebrain bundle have been successfully recorded wirelessly across multiple channels using 300-V/s fast-scan cyclic voltammetry.

Paper Details

Date Published: 29 August 2008
PDF: 11 pages
Proc. SPIE 7035, Biosensing, 70350O (29 August 2008); doi: 10.1117/12.796007
Show Author Affiliations
Masoud Roham, Case Western Reserve Univ. (United States)
Paul A. Garris, Illinois State Univ. (United States)
Pedram Mohseni, Case Western Reserve Univ. (United States)

Published in SPIE Proceedings Vol. 7035:
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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