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Proceedings Paper

Fourier transform infrared spectroscopy of deuterated proteins
Author(s): A. Marcano O.; Y. Markushin; N. Melikechi; D. Connolly
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Paper Abstract

We report on Fourier transform spectra of deuterated proteins: Bovine Serum Albumin, Leptin, Insulin-like Growth Factor II, monoclonal antibody to ovarian cancer antigen CA125 and Osteopontin. The spectra exhibit changes in the relative amplitude and spectral width of certain peaks. New peaks not present in the non-deuterated sample are also observed. Ways for improving the deuteration of proteins by varying the temperature and dilution time are discussed. We propose the use of deuterated proteins to increase the sensitivity of immunoassays aimed for early diagnostic of diseases most notably cancer.

Paper Details

Date Published: 2 September 2008
PDF: 8 pages
Proc. SPIE 7049, Linear and Nonlinear Optics of Organic Materials VIII, 70490Z (2 September 2008); doi: 10.1117/12.794878
Show Author Affiliations
A. Marcano O., Delaware State Univ. (United States)
Y. Markushin, Delaware State Univ. (United States)
N. Melikechi, Delaware State Univ. (United States)
D. Connolly, Fox Chase Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 7049:
Linear and Nonlinear Optics of Organic Materials VIII
Rachel Jakubiak, Editor(s)

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