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Proceedings Paper

Measurements of elastic constants between probe DNA strands and a target DNA linker
Author(s): Yun-Hui Park; Sun-Uk Hwang; Daekyung Sung; Dongkyu Kim; Sangyong Jon; Yong-Gu Lee
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Paper Abstract

This paper reports the measurement of elastic constants between two DNA strands that are simultaneously hybridized by a third target-DNA linker. Two probe-DNA strands that are immobilized on fluorescent beads and a target-DNA linker formed a hybridized assembly through the Watson-Crick based pairing. Elastic constants of the resulting assembly were measured using a force calibrated dual optical trap. This study can be used to detect the existence of a target-DNA linker with a specified nucleotide sequence, indicating its potential use in DNA biosensors.

Paper Details

Date Published: 29 August 2008
PDF: 9 pages
Proc. SPIE 7038, Optical Trapping and Optical Micromanipulation V, 703804 (29 August 2008); doi: 10.1117/12.794760
Show Author Affiliations
Yun-Hui Park, Gwangju Institute of Science and Technology (Korea, Republic of)
Sun-Uk Hwang, Gwangju Institute of Science and Technology (Korea, Republic of)
Daekyung Sung, Gwangju Institute of Science and Technology (Korea, Republic of)
Dongkyu Kim, Gwangju Institute of Science and Technology (Korea, Republic of)
Sangyong Jon, Gwangju Institute of Science and Technology (Korea, Republic of)
Yong-Gu Lee, Gwangju Institute of Science and Technology (Korea, Republic of)


Published in SPIE Proceedings Vol. 7038:
Optical Trapping and Optical Micromanipulation V
Kishan Dholakia; Gabriel C. Spalding, Editor(s)

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