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Proceedings Paper

Advances in the visualization of unstained brain tumors using grating-based x-ray phase-contrast tomography
Author(s): Franz Pfeiffer; Oliver Bunk; Christian David; Martin Bech; Geraldine Le Duc; Alberto Bravin; Peter Cloetens
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Paper Abstract

We report advances and complementary results concerning a recently developed method for high-sensitivity grating-based hard x-ray phase tomography. We demonstrate how the soft tissue sensitivity of the technique can be used to obtain in-vitro tomographic images of a tumor bearing rat brain specimen, without use of contrast agents. In particular, we demonstrate that brain tumors and the white and gray brain matter structure in a rat's cerebellum can be resolved by this approach. The findings are potentially interesting from a clinical point of view, since a similar approach using three transmission gratings can be implemented with more readily available x-ray sources, such as standard x-ray tubes. Moreover, open the results the way to in-vivo experiments in the near future.

Paper Details

Date Published: 16 September 2008
PDF: 10 pages
Proc. SPIE 7078, Developments in X-Ray Tomography VI, 707815 (16 September 2008); doi: 10.1117/12.794666
Show Author Affiliations
Franz Pfeiffer, Paul Scherrer Institut (Switzerland)
Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Oliver Bunk, Paul Scherrer Institut (Switzerland)
Christian David, Paul Scherrer Institut (Switzerland)
Martin Bech, Univ. of Copenhagen (Denmark)
Geraldine Le Duc, European Synchrotron Radiation Facility (France)
Alberto Bravin, European Synchrotron Radiation Facility (France)
Peter Cloetens, European Synchrotron Radiation Facility (France)

Published in SPIE Proceedings Vol. 7078:
Developments in X-Ray Tomography VI
Stuart R. Stock, Editor(s)

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