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Proceedings Paper

Comparative micro computed tomography study of a vertebral body
Author(s): Susanne Drews; Felix Beckmann; Julia Herzen; Oliver Brunke; Phil Salmon; Sebastian Friess; Andres Laib; Bruno Koller; Thomas Hemberger; Magdalena Müller-Gerbl; Bert Müller
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Paper Abstract

Investigations of bony tissues are often performed using micro computed tomography based on X-rays, since the calcium distribution leads to superior contrast. Osteoporotic bone, for example, can be well compared with healthy one with respect to density and morphology. Degenerative and rheumatoid diseases usually start, however, at the bone-cartilage-interface, which is hardly accessible. The direct influence on the bone itself becomes only visible at later stage. For the development of suitable therapies against degenerative cartilage damages the exact three-dimensional description of the bone-cartilage interface is vital, as demonstrated for transplanted cartilage-cells or bone-cartilage-constructs in animal models. So far, the morphological characterization was restricted to magnetic resonance imaging (MRI) with poor spatial resolution or to time-consuming histological sectioning with appropriate spatial resolution only in two rather arbitrarily chosen directions. Therefore, one should develop μCT to extract the features of low absorbing cartilage. The morphology and the volume of the inter-vertebral cartilage disc of lumbar motion segments have been determined for one PMMA embedded specimen. Tomograms were recorded using nanotom® (Phoenix|x-ray, Wunstorf, Germany), μCT 35TM (Scanco Medical, Brütisellen, Switzerland), 1172TM and 1174TM (both Skyscan, Kontich, Belgium), as well as using the SRμCT at HASYLAB/DESY. Conventional and SRμCT can provide the morphology and the volume of cartilage between bones. Increasing the acquisition time, the signal-to-noise ratio becomes better and better but the prominent artifacts in conventional μCT as the result of inhomogeneously distributed bony tissue prevents the exact segmentation of cartilage. SRμCT allows segmenting the cartilage but requires long periods of expensive beam-time to obtain reasonable contrast.

Paper Details

Date Published: 15 September 2008
PDF: 14 pages
Proc. SPIE 7078, Developments in X-Ray Tomography VI, 70780C (15 September 2008); doi: 10.1117/12.793815
Show Author Affiliations
Susanne Drews, Univ. Basel (Switzerland)
Kantonsspital Bruderholz (Switzerland)
Felix Beckmann, GKSS-Research Ctr. Geesthacht (Germany)
Julia Herzen, GKSS-Research Ctr. Geesthacht (Germany)
Oliver Brunke, phoenix|x-ray Systems + Services GmbH (Germany)
Phil Salmon, Skyscan N.V. (Belgium)
Sebastian Friess, Gloor Instruments AG (Switzerland)
Andres Laib, SCANCO Medical AG (Switzerland)
Bruno Koller, SCANCO Medical AG (Switzerland)
Thomas Hemberger, phoenix|x-ray Systems + Services GmbH (Germany)
Magdalena Müller-Gerbl, Univ. Basel (Switzerland)
Bert Müller, Univ. Basel (Switzerland)

Published in SPIE Proceedings Vol. 7078:
Developments in X-Ray Tomography VI
Stuart R. Stock, Editor(s)

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