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Proceedings Paper

Ultrashort relativistic electron bunches and spatio-temporal radiation biology
Author(s): Y. A. Gauduel; J. Faure; V. Malka
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Paper Abstract

The intensive developments of terawatt Ti:Sa lasers permit to extend laser-plasma interactions into the relativistic regime, providing very-short electron or proton bunches. Experimental researches developed at the interface of laser physics and radiation biology, using the combination of sub-picosecond electron beams in the energy range 2-15 MeV with femtosecond near-IR optical pulses might conjecture the real-time investigation of penetrating radiation effects. A perfect synchronization between the particle beam (pump) and optical beam at 820 nm (probe) allows subpicosecond time resolution. This emerging domain involves high-energy radiation femtochemistry (HERF) for which the early spatial energy deposition is decisive for the prediction of cellular and tissular radiation damages. With vacuum-focused intensities of 2.7 x 1019 W cm-2 and a high energy electron total charge of 2.5 nC, radiation events have been investigated in the temporal range 10-13 - 10-10s. The early radiation effects of secondary electron on biomolecular sensors may be investigated inside sub-micrometric ionisation, considering the radial direction of Gaussian electron bunches. It is shown that short range electron-biosensor interactions lower than 10 A take place in nascent track structures triggered by penetrating radiation bunches. The very high dose delivery 1013 Gy s-1 performed with laser plasma accelerator may challenge our understanding of nanodosimetry on the time scale of molecular target motions. High-quality ultrashort penetrating radiation beams open promising opportunities for the development of spatio-temporal radiation biology, a crucial domain of cancer therapy, and would favor novating applications in nanomedicine such as highly-selective shortrange pro-drug activation.

Paper Details

Date Published: 3 September 2008
PDF: 14 pages
Proc. SPIE 7080, Penetrating Radiation Systems and Applications IX, 708002 (3 September 2008); doi: 10.1117/12.793733
Show Author Affiliations
Y. A. Gauduel, Ecole Polytechnique - ENS Techniques Avancées (France)
J. Faure, Ecole Polytechnique - ENS Techniques Avancées (France)
V. Malka, Ecole Polytechnique - ENS Techniques Avancées (France)

Published in SPIE Proceedings Vol. 7080:
Penetrating Radiation Systems and Applications IX
F. Patrick Doty; H. Bradford Barber; Hans Roehrig; Richard C Schirato, Editor(s)

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