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Proceedings Paper

Novel Raman signal recovery from deeply buried tissue components
Author(s): Nicholas Stone; Rebecca Baker; Consuelo Hart Prieto; Pavel Matousek
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Paper Abstract

A program of work has been established to explore the possibility of sampling Raman information from material deeply buried within tissues. Time-gating, spatial offsetting of source and collection (spatially offset Raman spectroscopy) and transmission approaches have been explored. This invited contribution will outline these and the limitations of each technique will be discussed. Time-gating allows well defined depth selection, but with low penetrations of the order of 1- 2mm; whereas SORS has allowed some depth selection and an order of magnitude greater depth range; the use of transmission Raman spectroscopy has permitted greater depths of penetration, but depth selection is not possible in this configuration. To date transmission Raman has demonstrated recovery of compositional information through 27mm of mammalian tissue. Furthermore, a first demonstration of Kerr-gated Raman spectroscopy for fluorescence suppression in resonance Raman measurements of liver and kidney is also outlined.

Paper Details

Date Published: 3 March 2008
PDF: 15 pages
Proc. SPIE 6853, Biomedical Optical Spectroscopy, 68530N (3 March 2008); doi: 10.1117/12.786442
Show Author Affiliations
Nicholas Stone, Gloucestershire Royal Hospital (United Kingdom)
Rebecca Baker, Gloucestershire Royal Hospital (United Kingdom)
Consuelo Hart Prieto, Gloucestershire Royal Hospital (United Kingdom)
Pavel Matousek, Rutherford Appleton Lab. (United Kingdom)

Published in SPIE Proceedings Vol. 6853:
Biomedical Optical Spectroscopy
Anita Mahadevan-Jansen; Wolfgang Petrich; Robert R. Alfano; Alvin Katz, Editor(s)

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