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Proceedings Paper

Synthesis and functionalization of non-toxic visible-emitting nanocrystals
Author(s): Yingchuan Chen; Leah Page; Rahul Thakar; Preston T. Snee
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Paper Abstract

We have studied phosphor doping of core / shell nanocrystals (NCs) where the impurity emitter resides in the shell. We have found that a two step synthesis can be used to create these non-toxic materials that efficiently transfer energy from the core to the doped shell. These core / shell NCs retain ample brightness when solubilized in water. We explored the functionalization of these materials in water as well to create ratiometric chemical sensing agents. First, we used a method of controlled polymerization to synthesize amphiphilic polymers to solubilize the intrinsically hydrophobic NCs into water. The polymer has a build in "chemical handle" which we use to functionalize the polymers closely bound to the NC with a fluorescent dye in aqueous solution. We have found that there exists efficient Förster resonant energy transfer from the shell doped phosphors to the surface bound dyes. Conjugation of the NC to an environmentally sensitive dye such as fluorescein has also demonstrated that non-toxic doped NCs can be used to develop ratiometric sensing / biological imaging agents. Last, we have found that the same technique can be applied to functionalize non-emissive magnetic nanocrystals as well.

Paper Details

Date Published: 22 February 2008
PDF: 9 pages
Proc. SPIE 6866, Colloidal Quantum Dots for Biomedical Applications III, 686603 (22 February 2008); doi: 10.1117/12.784058
Show Author Affiliations
Yingchuan Chen, Univ. of Illinois at Chicago (United States)
Leah Page, Univ. of Illinois at Chicago (United States)
Rahul Thakar, Univ. of Illinois at Chicago (United States)
Preston T. Snee, Univ. of Illinois at Chicago (United States)


Published in SPIE Proceedings Vol. 6866:
Colloidal Quantum Dots for Biomedical Applications III
Marek Osinski; Thomas M. Jovin; Kenji Yamamoto, Editor(s)

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