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Proceedings Paper

Targeting the human serotonin transporter (hSERT) with quantum dots
Author(s): I. D. Tomlinson; Jerry Chang; Hideki Iwamoto; Louis J. De Felice; Randy D. Blakely; Sandra J. Rosenthal
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Paper Abstract

In this paper we report our work on the development of a human serotonin transporter (hSERT) antagonist that can be conjugated to quantum dots. This approach has been used to target and visualize the human serotonin transporter protein (hSERT). We demonstrate that labeling is blocked by the addition of high affinity hSERT antagonists such as paroxetine. This approach may be useful for the development of fluorescent assays to study the location and temporal dynamics of biogenic amine transporters and also holds promise for the development of plate-based high throughput assays used to identify novel transporter antagonists.

Paper Details

Date Published: 26 February 2008
PDF: 12 pages
Proc. SPIE 6866, Colloidal Quantum Dots for Biomedical Applications III, 68660X (26 February 2008); doi: 10.1117/12.782801
Show Author Affiliations
I. D. Tomlinson, Vanderbilt Univ. (United States)
Jerry Chang, Vanderbilt Univ. (United States)
Hideki Iwamoto, Vanderbilt Univ. School of Medicine (United States)
Louis J. De Felice, Vanderbilt Univ. School of Medicine (United States)
Randy D. Blakely, Vanderbilt Univ. School of Medicine (United States)
Sandra J. Rosenthal, Vanderbilt Univ. (United States)
Vanderbilt Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 6866:
Colloidal Quantum Dots for Biomedical Applications III
Marek Osinski; Thomas M. Jovin; Kenji Yamamoto, Editor(s)

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