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Proceedings Paper

Non-invasive dry mass determination and monitoring at the single cell level with digital holographic microscopy
Author(s): Benjamin Rappaz; Elena Cano; Jonas Kühn; Tristan Colomb; Christian Depeursinge; Pierre J. Magistretti; Pierre Marquet
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Paper Abstract

Digital holography microscopy (DHM) is an optical microscopy technique which allows recording non-invasively the phase shift induced by living cells with nanometric sensitivity. Here, we exploit the phase signal as an indicator of dry mass (related to the protein concentration). This parameter allows monitoring the protein production rate and its evolution during the cell cycle.

Paper Details

Date Published: 2 May 2008
PDF: 4 pages
Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699111 (2 May 2008); doi: 10.1117/12.781565
Show Author Affiliations
Benjamin Rappaz, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Elena Cano, Swiss Institute for Experimental Cancer Research (Switzerland)
Jonas Kühn, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Tristan Colomb, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Christian Depeursinge, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Pierre J. Magistretti, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Pierre Marquet, Ctr. de Neurosciences Psychiatriques, CHUV (Switzerland)


Published in SPIE Proceedings Vol. 6991:
Biophotonics: Photonic Solutions for Better Health Care
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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