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Proceedings Paper

Modeling of epithelia transport phenomena related with the acetowhitening optical changes: potential for the in vivo diagnosis of cervical neoplasia
Author(s): George Papoutsoglou; Antonis Potirakis; Costas Balas
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Paper Abstract

A molecular imaging method employing acetic acid dilute solution as a biomarker of cervical neoplasia is described and the interpretation of the biophysical processes involved determining the in-vivo measured dynamic scattering characteristics is presented. A compartmental model of the epithelium has been developed for predicting the epithelial transport phenomena that are expected to be correlated with the dynamic characteristics of the backscattered light. Model predictions have been compared and confirmed by experimental data obtained from patients with cervical neoplasia of different grade, with the aid of specially developed imaging system. Results revealed that the dynamic scattering characteristics and both structural and functional alterations are largely determined by the intracellular proton concentration kinetics. This highlights the potential of the developed imaging method and technology for the non-invasive diagnosis, guided therapeutics and screening of cervical neoplasia.

Paper Details

Date Published: 8 May 2008
PDF: 7 pages
Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 69912C (8 May 2008); doi: 10.1117/12.781501
Show Author Affiliations
George Papoutsoglou, Technical Univ. of Crete (Greece)
Antonis Potirakis, Technical Univ. of Crete (Greece)
Costas Balas, Technical Univ. of Crete (Greece)
Forth-Photonics, UK & Greece (Greece)

Published in SPIE Proceedings Vol. 6991:
Biophotonics: Photonic Solutions for Better Health Care
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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