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Proceedings Paper

Combined Monte Carlo and finite-difference time-domain modeling for biophotonic analysis
Author(s): Yasser R. Hijazi; Cemre Kortun; Dizem Arifler
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Paper Abstract

Monte Carlo (MC) modeling is widely used to study photon transport in tissues but is generally performed using simplified phase functions that only approximate the angular scattering probability distribution of microscopic tissue constituents such as cells. Finite-Difference Time-Domain (FDTD) modeling has recently provided a flexible approach to compute scattering phase functions for realistic cell geometries. We present a computational framework that combines MC and FDTD modeling and allows random sampling of scattering directions from cellular phase functions computed using the FDTD method. Combined MC/FDTD simulation results indicate that the exact form of the phase function used is an important factor in determining the modeled optical response of tissues. Subtle differences in angular scattering probability distribution can lead to significant changes in detected reflectance intensity and the extent of these changes depends on the specific range of scattering angles to which a given optical sensor design is most sensitive.

Paper Details

Date Published: 2 May 2008
PDF: 10 pages
Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699129 (2 May 2008); doi: 10.1117/12.781378
Show Author Affiliations
Yasser R. Hijazi, Eastern Mediterranean Univ. (Cyprus)
Cemre Kortun, Univ. College London (United Kingdom)
Dizem Arifler, Eastern Mediterranean Univ. (Cyprus)

Published in SPIE Proceedings Vol. 6991:
Biophotonics: Photonic Solutions for Better Health Care
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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