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Proceedings Paper

Preprocessing and analysis of microarray images from integrated lensless bio-photonic sensors
Author(s): Jesús Angulo; Christian Lajaunie; Michel Bilodeau; Lucio Martinelli; Françoise Le Boulaire; Fernand Meyer
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Paper Abstract

A new integrated lensless bio-photonic sensors is being developed. It replaces the ordinary slide supporting the DNA spots, and the complex, large and expensive hybridisation and the scanner reading system, by a sandwich of well defined chemical and optical layers grafted onto a CCD sensor. The upper layer of the new biochip performs the biological function. Due to the architecture of the biochip leading to a lensless imaging of the spots directly on the sensor pixels, the images produced will have novel characteristics beyond the analysis capacity of reading software packages of microarray analysis. In this framework, specific image processing and statistical data analysis algorithms have been developed in order to assess and to quantify these images.

Paper Details

Date Published: 6 May 2008
PDF: 12 pages
Proc. SPIE 7000, Optical and Digital Image Processing, 700014 (6 May 2008); doi: 10.1117/12.781377
Show Author Affiliations
Jesús Angulo, Ecole des Mines de Paris (France)
Christian Lajaunie, Ecole des Mines de Paris (France)
Michel Bilodeau, Ecole des Mines de Paris (France)
Lucio Martinelli, Genewave S.A.S. (France)
Françoise Le Boulaire, Genewave S.A.S. (France)
Fernand Meyer, Ecole des Mines de Paris (France)

Published in SPIE Proceedings Vol. 7000:
Optical and Digital Image Processing
Peter Schelkens; Touradj Ebrahimi; Gabriel Cristóbal; Frédéric Truchetet, Editor(s)

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