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Proceedings Paper

Self-calibrated dynamical optical biochip system using surface plasmon resonance imaging: application to genotyping
Author(s): Jérôme Hottin; Julien Moreau; Jolanda Spadavecchia; Alain Bellemain; Laure Lecerf; Michel Goossens; Michael Canva
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Paper Abstract

The present paper summarizes some of our work in the field of genetic diagnosis using Surface Plasmon Resonance Imaging. The optical setup and its capability are presented, as well as the gold surface functionalization used. Results obtained with oligonucleotides targets, specific to Cystic Fibrosis disease, in high and low concentration are shown. The self-calibration method we have developed to reduce data dispersion in genetic diagnosis applications is described.

Paper Details

Date Published: 9 May 2008
PDF: 11 pages
Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 69910Q (9 May 2008); doi: 10.1117/12.781364
Show Author Affiliations
Jérôme Hottin, Lab. Charles Fabry de l'Institut d'Optique, Univ. Paris-Sud, CNRS (France)
Julien Moreau, Lab. Charles Fabry de l'Institut d'Optique, Univ. Paris-Sud, CNRS (France)
Jolanda Spadavecchia, Lab. Charles Fabry de l'Institut d'Optique, Univ. Paris-Sud, CNRS (France)
Alain Bellemain, Lab. Charles Fabry de l'Institut d'Optique, Univ. Paris-Sud, CNRS (France)
Laure Lecerf, INSERM, Univ. Paris 12 (France)
Michel Goossens, INSERM, Univ. Paris 12 (France)
Michael Canva, Lab. Charles Fabry de l'Institut d'Optique, Univ. Paris-Sud, CNRS (France)


Published in SPIE Proceedings Vol. 6991:
Biophotonics: Photonic Solutions for Better Health Care
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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