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Proceedings Paper

New optical analyzer for 13C-breath test
Author(s): Hermann Harde; Matthias Dressler; Günther Helmrich; Marcus Wolff; Hinrich Groninga
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Paper Abstract

Medical breath tests are well established diagnostic tools, predominantly for gastroenterological inspections, but also for many other examinations. Since the composition and concentration of exhaled volatile gases reflect the physical condition of a patient, a breath analysis allows one to recognize an infectious disease in an organ or even to identify a tumor. One of the most prominent breath tests is the 13C-urea-breath test, applied to ascertain the presence of the bacterium helicobacter pylori in the stomach wall as an indication of a gastric ulcer. In this contribution we present a new optical analyzer that is based on photoacoustic spectroscopy and uses a DFB diode laser at 2.744 μm. The concentration ratio of the CO2 isotopologues is determined by measuring the absorption on a 13CO2 line in comparison to a 12CO2 line. In the specially selected spectral range the lines have similar strengths, although the concentrations differ by a factor of 90. Therefore, the signals are well comparable. Due to an excellent signal-noise-ratio isotope variations of less than 1% can be resolved as required for the breath test.

Paper Details

Date Published: 2 May 2008
PDF: 9 pages
Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 69910T (2 May 2008); doi: 10.1117/12.781271
Show Author Affiliations
Hermann Harde, Helmut-Schmidt-Univ. (Germany)
Matthias Dressler, Helmut-Schmidt-Univ. (Germany)
Günther Helmrich, Helmut-Schmidt-Univ. (Germany)
Marcus Wolff, PAS-Tech Gasanalytik GmbH (Germany)
Hinrich Groninga, PAS-Tech Gasanalytik GmbH (Germany)

Published in SPIE Proceedings Vol. 6991:
Biophotonics: Photonic Solutions for Better Health Care
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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