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Proceedings Paper

Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions
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Paper Abstract

We investigate vascular changes during Photodynamic therapy (PDT) of skin tumors using optical Doppler tomography (ODT). The effect of vascular shut down on tumor destruction is currently not known, and to optimize treatment it is relevant to investigate this issue further. Optical Doppler tomography is capable of measuring blood flow in biological tissue down to 1-2 mm with sub-mm/s velocity sensitivity and micrometer spatial resolution making it suitable for blood flow measurements in the skin. We demonstrate the ability of detecting blood flow in the human skin using non-interstitial ODT to preserve the non-invasiveness. In general a very limited blood flow activity was observed in normal skin and around skin tumors making monitoring of changes difficult. We suggest solutions to a number of practical issues such as sampling errors and natural fluctuations in flow activity for future work.

Paper Details

Date Published: 2 May 2008
PDF: 7 pages
Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699118 (2 May 2008); doi: 10.1117/12.781142
Show Author Affiliations
J. Thomsen, Technical Univ. of Denmark (Denmark)
N. Bendsøe, Lund Univ. Hospital (Sweden)
K. Svanberg M.D., Lund Univ. Hospital (Sweden)
S. Andersson-Engels, Lund Univ. (Sweden)
T. M. Jørgensen, Technical Univ. of Denmark (Denmark)
L. Thrane, Technical Univ. of Denmark (Denmark)
H. E. Larsen, Technical Univ. of Denmark (Denmark)
F. Pedersen, Technical Univ. of Denmark (Denmark)
P. E. Andersen, Technical Univ. of Denmark (Denmark)

Published in SPIE Proceedings Vol. 6991:
Biophotonics: Photonic Solutions for Better Health Care
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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