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Proceedings Paper

Coherent optical imaging and guided interventions in breast cancer: translating technology into clinical applications
Author(s): Stephen A. Boppart; Freddy T. Nguyen; Adam M. Zysk; Eric J. Chaney; Jan G. Kotynek; Uretz J. Oliphant; Frank J. Bellafiore; Kendrith M. Rowland; Patricia A. Johnson
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Paper Abstract

Breast cancer continues to be one of the most widely diagnosed forms of cancer in women and the second leading type of cancer deaths for women. The metastatic spread and staging of breast cancer is typically evaluated through the nodal assessment of the regional lymphatic system, and often this is performed during the surgical resection of the tumor mass. The recurrence rate of breast cancer is highly dependent on several factors including the complete removal of the primary tumor during surgery, and the presence of cancer cells in involved lymph nodes. Hence, developing means to more accurately resect tumor cells, along with the tumor mass, and ensure negative surgical margins, offers the potential to impact outcomes of breast cancer. The use of diffuse optical tomography has been applied for screening optical mammography applications as an alternative to standard x-ray mammography. The use of coherence ranging and coherent optical imaging in breast tissue has also found numerous applications, including intra-operative assessment of tumor margin status during lumpectomy procedures, assessment of lymph node changes for staging metastatic spread, and for guiding needle-biopsy procedures. The development, pre-clinical testing, and translation of techniques such as low-coherence interferometry (LCI) and optical coherence tomography (OCT) into clinical applications in breast cancer is demonstrated in these feasibility studies.

Paper Details

Date Published: 17 April 2008
PDF: 12 pages
Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699102 (17 April 2008); doi: 10.1117/12.780168
Show Author Affiliations
Stephen A. Boppart, Univ. of Illinois at Urbana-Champaign (United States)
Mills Breast Cancer Institute (United States)
Freddy T. Nguyen, Univ. of Illinois at Urbana-Champaign (United States)
Adam M. Zysk, Univ. of Illinois at Urbana-Champaign (United States)
Eric J. Chaney, Univ. of Illinois at Urbana-Champaign (United States)
Jan G. Kotynek, Univ. of Illinois at Urbana-Champaign (United States)
Mills Breast Cancer Institute (United States)
Uretz J. Oliphant, Univ. of Illinois at Urbana-Champaign (United States)
Mills Breast Cancer Institute (United States)
Frank J. Bellafiore, Univ. of Illinois at Urbana-Champaign (United States)
Mills Breast Cancer Institute (United States)
Kendrith M. Rowland, Univ. of Illinois at Urbana-Champaign (United States)
Mills Breast Cancer Institute (United States)
Patricia A. Johnson, Univ. of Illinois at Urbana-Champaign (United States)
Mills Breast Cancer Institute (United States)


Published in SPIE Proceedings Vol. 6991:
Biophotonics: Photonic Solutions for Better Health Care
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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