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Proceedings Paper

Optical microscopy with nanometer resolution for single molecule detection
Author(s): Guiying Wang; Guo Fu; Chen Wang; Zenghui Zhou; Li Liu; Ruxin Li
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Paper Abstract

Fluorescence microscopies with nanometer-distance resolution to locate the position and track individual single molecules were developed and applied. We focused on quantitatively study of the motion of lipid-anchor green fluorescent proteins with an oblique illumination mode of the microscope. A protein dynamics was analyzed using a photon statistics. In addition, fluorescence resonance energy transfer (FRET) microscopy and surface enhance Ranman spectroscopy (SERS) studies etc. were also introduced in this report .

Paper Details

Date Published: 8 January 2008
PDF: 9 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 682612 (8 January 2008); doi: 10.1117/12.778585
Show Author Affiliations
Guiying Wang, Shanghai Institute of Optics and Fine Mechanics (China)
Guo Fu, Shanghai Institute of Optics and Fine Mechanics (China)
Chen Wang, Shanghai Institute of Optics and Fine Mechanics (China)
Zenghui Zhou, Shanghai Institute of Optics and Fine Mechanics (China)
Li Liu, Shanghai Institute of Optics and Fine Mechanics (China)
Ruxin Li, Shanghai Institute of Optics and Fine Mechanics (China)


Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu, Editor(s)

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