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Proceedings Paper

Micromechanical sensors based on conformational change of proteins
Author(s): Xin Yang; Koutilya R. Buchapudi; Hongyan Gao; Xiaohe Xu; Hai-Feng Ji
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Paper Abstract

Microcantilevers (MCLs) hold a position as a cost-effective and highly sensitive sensor platform for medical diagnostics, environmental, and fast throughput analysis. One of recently focus in this technology is the development of biosensors based on the conformational change of proteins on MCL surfaces. The surface stress changes due to conformational change of the proteins upon interaction with specific analytes are promising as transducers of chemical information. We will discuss our recent results on several biosensors due to conformational change of proteins. The proteins include glucose oxidase (GOx), organophosphorus hydrolyses (OPH), Calmodulin (CaM), and Horseradish peroxidase (HRP).

Paper Details

Date Published: 30 April 2008
PDF: 7 pages
Proc. SPIE 6959, Micro (MEMS) and Nanotechnologies for Space, Defense, and Security II, 69590N (30 April 2008); doi: 10.1117/12.776180
Show Author Affiliations
Xin Yang, Louisiana Tech Univ. (United States)
Koutilya R. Buchapudi, Louisiana Tech Univ. (United States)
Hongyan Gao, Louisiana Tech Univ. (United States)
Xiaohe Xu, Louisiana Tech Univ. (United States)
Hai-Feng Ji, Louisiana Tech Univ. (United States)

Published in SPIE Proceedings Vol. 6959:
Micro (MEMS) and Nanotechnologies for Space, Defense, and Security II
Thomas George; Zhongyang Cheng, Editor(s)

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