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Proceedings Paper

Controlled assembly of gold nanoparticles using De Novo designed polypeptide scaffolds
Author(s): Daniel Aili; Hsu Shu Han; Karin Enander; Lars Baltzer; Bo Liedberg
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Paper Abstract

Heterodimerization between designed helix-loop-helix polypeptides was utilized in order to assemble gold nanoparticles on planar substrates. The peptides were designed to fold into four-helix bundles upon dimerization. A Cys-residue in the loop region was used to immobilize one of the complementary peptides on a maleimide containing SAM on planar gold substrates whereas the second peptide was immobilized directly on gold nanoparticles. Introducing the peptide decorated particles over a peptide functionalized surface resulted in particle assembly. Further, citrate stabilized particles were assembled on amino-silane modified glass and silicon substrates. By subsequently introducing peptides and gold nanoparticles, particle-peptide hybrid multi layers could be formed.

Paper Details

Date Published: 20 February 2008
PDF: 8 pages
Proc. SPIE 6885, MEMS/MOEMS Components and Their Applications V. Special Focus Topics: Transducers at the Micro-Nano Interface, 688506 (20 February 2008); doi: 10.1117/12.775806
Show Author Affiliations
Daniel Aili, Linköping Univ. (Sweden)
Hsu Shu Han, Linköping Univ. (Sweden)
Karin Enander, Linköping Univ. (Sweden)
Lars Baltzer, Uppsala Univ. (Sweden)
Bo Liedberg, Linköping Univ. (Sweden)


Published in SPIE Proceedings Vol. 6885:
MEMS/MOEMS Components and Their Applications V. Special Focus Topics: Transducers at the Micro-Nano Interface
Srinivas A. Tadigadapa; Babak A. Parviz; Albert K. Henning, Editor(s)

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