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Proceedings Paper

Specific in vivo labeling with GFP retroviruses, lentiviruses, and adenoviruses for imaging
Author(s): Robert M. Hoffman; Hiroyuki Kishimoto; Toshiyoshi Fujiwara
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Paper Abstract

Fluorescent proteins have revolutionized the field of imaging. Our laboratory pioneered in vivo imaging with fluorescent proteins. Fluorescent proteins have enabled imaging at the subcellular level in mice. We review here the use of different vectors carrying fluorescent proteins to selectively label normal and tumor tissue in vivo. We show that a GFP retrovirus and telomerase-driven GFP adenovirus can selectively label tumors in mice. We also show that a GFP lentivirus can selectively label the liver in mice. The practical application of these results are discussed.

Paper Details

Date Published: 29 February 2008
PDF: 6 pages
Proc. SPIE 6868, Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes, 68680F (29 February 2008); doi: 10.1117/12.773308
Show Author Affiliations
Robert M. Hoffman, AntiCancer, Inc. (United States)
Univ. of California, San Diego (United States)
Hiroyuki Kishimoto, AntiCancer, Inc. (United States)
Univ. of California, San Diego (United States)
Okayama Univ. Graduate School of Medicine (Japan)
Toshiyoshi Fujiwara, Okayama Univ. Graduate School of Medicine (Japan)


Published in SPIE Proceedings Vol. 6868:
Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes
Alexander P. Savitsky; Robert E. Campbell; Robert M. Hoffman, Editor(s)

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