Share Email Print

Proceedings Paper

Validation of a GEANT4 simulation of neutron stimulated emission computed tomography
Author(s): Anuj J. Kapadia; Brian P. Harrawood; Georgia D. Tourassi
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Neutron stimulated emission computed tomography (NSECT) is being proposed as a non-invasive technique to detect concentrations of elements in the body for diagnosis of liver iron overload. Several experiments have been conducted to investigate NSECT's ability to determine iron concentration in liver tissue and evaluate the accuracy and sensitivity of the system. While these experiments have been successful in demonstrating NSECT's capability of quantifying iron and other tissue elements in-vivo, they have been prohibitively time consuming, often requiring as much as 24 hour acquisitions for accurate quantification. Such extensive scan times limit the use of the experimental system for initial feasibility testing and optimization. As a practical alternative, GEANT4 simulations are being developed to investigate system optimization and aid further progress of the experimental technique. This work presents results of a validation study comparing the results of a GEANT4 simulation with experimental data obtained from a sample of iron. A simulation of the NSECT system is implemented in GEANT4 and used to acquire a spectrum from a simulated iron sample. Scanning is performed with a 7.5 MeV neutron beam to stimulate gamma emission from iron nuclei. The resulting gamma spectrum is acquired and reconstructed using high-purity germanium (HPGe) detectors and analyzed for energy peaks corresponding to iron. The simulated spectrum is compared with a corresponding experimental spectrum acquired with an identical source-detector-sample configuration. Five peaks are detected corresponding to gamma transitions from iron in both spectra with relative errors ranging from 4.5% to 17% for different peaks. The result validates the GEANT4 simulation as a feasible alternative to perform simulated NSECT experiments using only computational resources.

Paper Details

Date Published: 18 March 2008
PDF: 6 pages
Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 69133H (18 March 2008); doi: 10.1117/12.773196
Show Author Affiliations
Anuj J. Kapadia, Duke Univ. Medical Ctr. (United States)
Brian P. Harrawood, Duke Univ. Medical Ctr. (United States)
Georgia D. Tourassi, Duke Univ. Medical Ctr. (United States)
Duke Univ. (United States)

Published in SPIE Proceedings Vol. 6913:
Medical Imaging 2008: Physics of Medical Imaging
Jiang Hsieh; Ehsan Samei, Editor(s)

© SPIE. Terms of Use
Back to Top