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Proceedings Paper

Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography
Author(s): Yakov Nesterets; Tim Gureyev; Andrew Stevenson; Andrew Pogany; Steve Wilkins; Russell Kincaid; Hongwei Ye; Levon Vogelsang; Edward Lipson; Ioana Coman; Sylvain Fourmaux; Jean-Claude Kieffer; Andrzej Krol
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Paper Abstract

To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.

Paper Details

Date Published: 25 March 2008
PDF: 7 pages
Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 69133Z (25 March 2008); doi: 10.1117/12.772761
Show Author Affiliations
Yakov Nesterets, CSIRO Manufacturing and Materials Technology (Australia)
Tim Gureyev, CSIRO Manufacturing and Materials Technology (Australia)
Andrew Stevenson, CSIRO Manufacturing and Materials Technology (Australia)
Andrew Pogany, CSIRO Manufacturing and Materials Technology (Australia)
Steve Wilkins, CSIRO Manufacturing and Materials Technology (Australia)
Russell Kincaid, Syracuse Univ. (United States)
Hongwei Ye, Syracuse Univ. (United States)
Levon Vogelsang, Syracuse Univ. (United States)
Edward Lipson, Syracuse Univ. (United States)
SUNY Upstate Medical Univ. (United States)
Ioana Coman, SUNY Upstate Medical Univ. (United States)
Sylvain Fourmaux, Univ. du Québec (Canada)
Jean-Claude Kieffer, Univ. du Québec (Canada)
Andrzej Krol, SUNY Upstate Medical Univ. (United States)
Syracuse Univ. (United States)


Published in SPIE Proceedings Vol. 6913:
Medical Imaging 2008: Physics of Medical Imaging
Jiang Hsieh; Ehsan Samei, Editor(s)

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