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Proceedings Paper

Intramyocardial capillary blood volume estimated by whole-body CT: validation by micro-CT
Author(s): Yue Dong; Patricia E. Beighley; Diane R Eaker; Mair Zamir; Erik L. Ritman
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Paper Abstract

Fast CT has shown that myocardial perfusion (F) is related to myocardial intramuscular blood volume (Bv) as Bv=A*F+B*F1/2 where A,B are constant coefficients. The goal of this study was to estimate the range of diameters of the vessels that are represented by the A*F term. Pigs were placed in an Electron Beam CT (EBCT) scanner for a perfusion CT scan sequence over 40 seconds after an IV contrast agent injection. Intramyocardial blood volume (Bv) and flow (F) were calculated in a region of the myocardium perfused by the LAD. Coefficients A and B were estimated over the range of F=1-5ml/g/min. After the CT scan, the LAD was injected with Microfil(R) contrast agent following which the myocardium was scanned by micro-CT at 20μm, 4μm and 2.5 μm cubic voxel resolutions. The Bv of the intramyocardial vessels was calculated for diameter ranges d=0-5, 5-10, 10-15, 15-20μm, etc. EBCT-derived data were presented so that it could be directly compared the micro-CT data. The results indicated that the blood in vessels less than 10μm in lumen diameter occupied 0.27-0.42 of total intravascular blood volume, which is in good agreement with EBCT-based values 0.28-0.48 (R2 =0.96). We conclude that whole-body CT image data obtained during the passage of a bolus of IV contrast agent can provide a measure of the intramyocardial intracapillary blood volume.

Paper Details

Date Published: 12 March 2008
PDF: 6 pages
Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 691624 (12 March 2008); doi: 10.1117/12.772713
Show Author Affiliations
Yue Dong, Mayo Clinic College of Medicine (United States)
Patricia E. Beighley, Mayo Clinic College of Medicine (United States)
Diane R Eaker, Mayo Clinic College of Medicine (United States)
Mair Zamir, Univ. of Western Ontario (Canada)
Erik L. Ritman, Mayo Clinic College of Medicine (United States)

Published in SPIE Proceedings Vol. 6916:
Medical Imaging 2008: Physiology, Function, and Structure from Medical Images
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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