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Proceedings Paper

Histopathology and MR image fusion of the prostate
Author(s): Hyun Hee Jo; Julip Jung; Yujin Jang; Helen Hong; Hak Jong Lee
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Paper Abstract

We propose a method for combining histopathology image with MR image of the prostate by using image correction and nonrigid registration. Our method consists of four steps. First, two or four tissue sections of the prostate in histopathology image are combined to produce a single prostate image by stitching. Second, the intensity of prostate bleeding area on T2-weighted MR image is substituted for that on T1-weighted MR image. Our intensity correction prevents a mistake which a prostate bleeding is considered as a tumor on T2-weighted MR image. Third, rough and fine registration is performed to find the best match for pixel overlap between histopathology and MR images. Then the result of rigid registration is deformed by the TPS warping. Finally, aligned images are visualized by the intensity intermixing. Experimental results show that the prostate tumor lesion can be properly located and clearly visualized within MR images for tissue characterization comparison.

Paper Details

Date Published: 11 March 2008
PDF: 7 pages
Proc. SPIE 6914, Medical Imaging 2008: Image Processing, 691430 (11 March 2008); doi: 10.1117/12.771380
Show Author Affiliations
Hyun Hee Jo, Seoul Women's Univ. (South Korea)
Julip Jung, Seoul Women's Univ. (South Korea)
Yujin Jang, Seoul Women's Univ. (South Korea)
Helen Hong, Seoul Women's Univ. (South Korea)
Hak Jong Lee, Seoul National University Bundang Hospital (South Korea)

Published in SPIE Proceedings Vol. 6914:
Medical Imaging 2008: Image Processing
Joseph M. Reinhardt; Josien P. W. Pluim, Editor(s)

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