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Proceedings Paper

Hyperpolarized helium-3 magnetic resonance imaging of asthma: short-term reproducibility
Author(s): Andrew Wheatley; Shayna McKay; Lindsay Mathew; Giles Santyr; David G. McCormack; Grace Parraga
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Paper Abstract

We examined subjects with exercise-induced asthma to assess the short-term reproducibility of hyperpolarized (Hp) helium-3 (3He) magnetic resonance imaging (MRI) of regional ventilation defects before asthma exacerbation. Our objective was to evaluate pre-exercise interscan Hp 3He MRI measurement reproducibility of subjects scanned on three separate occasions (5 ± 2 days between sessions). Magnetic resonance imaging was performed at 3.0 Tesla with a custom-built rigid elliptical 3He chest coil. Images for six subjects were evaluated by two observers; one who quantified ventilation defect score and ventilation defect volume and another who quantified percent ventilated volume. For all six subjects, pre-exercise ventilation defect location and number of defects were similar at all three visits suggesting persistence of many defects, but changes in defect volume and percent ventilated volume were detected.

Paper Details

Date Published: 12 March 2008
PDF: 8 pages
Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 69161X (12 March 2008); doi: 10.1117/12.771138
Show Author Affiliations
Andrew Wheatley, Robarts Research Institute (Canada)
Shayna McKay, Robarts Research Institute (Canada)
Lindsay Mathew, Robarts Research Institute (Canada)
Univ. of Western Ontario (Canada)
Giles Santyr, Robarts Research Institute (Canada)
Univ. of Western Ontario (Canada)
David G. McCormack, Robarts Research Institute (Canada)
Univ. of Western Ontario (Canada)
Grace Parraga, Robarts Research Institute (Canada)
Univ. of Western Ontario (Canada)


Published in SPIE Proceedings Vol. 6916:
Medical Imaging 2008: Physiology, Function, and Structure from Medical Images
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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