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Proceedings Paper

Novel kinetic texture features for breast lesion classification on dynamic contrast enhanced (DCE) MRI
Author(s): Shannon C. Agner; Salil Soman; Edward Libfeld; Margie McDonald; Mark A. Rosen; Mitchell D. Schnall; Deanna Chin; John Nosher; Anant Madabhushi
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Paper Abstract

Dynamic contrast enhanced (DCE) MRI has emerged as a promising new imaging modality for breast cancer screening. Currently, radiologists evaluate breast lesions based on qualitative description of lesion morphology and contrast uptake profiles. However, the subjectivity associated with qualitative description of breast lesions on DCE-MRI introduces a high degree of inter-observer variability. In addition, the high sensitivity of MRI results in poor specificity and thus a high rate of biopsies on benign lesions. Computer aided diagnosis (CAD) methods have been previously proposed for breast MRI, but research in the field is far from comprehensive. Most previous work has focused on either quantifying morphological attributes used by radiologists, characterizing lesion intensity profiles which reflect uptake of contrast dye, or characterizing lesion texture. While there has been much debate on the relative importance of the different classes of features (e.g., morphological, textural, and kinetic), comprehensive quantitative comparisons between the different lesion attributes have been rare. In addition, although kinetic signal enhancement curves may give insight into the underlying physiology of the lesion, signal intensity is susceptible to MRI acquisition artifacts such as bias field and intensity non-standardness. In this paper, we introduce a novel lesion feature that we call the kinetic texture feature, which we demonstrate to be superior compared to the lesion intensity profile dynamics. Our hypothesis is that since lesion intensity is susceptible to artifacts, lesion texture changes better reflect lesion class (benign or malignant). In this paper, we quantitatively demonstrate the superiority of kinetic texture features for lesion classification on 18 breast DCE-MRI studies compared to over 500 different morphological, kinetic intensity, and lesion texture features. In conjunction with linear and non-linear dimensionality reduction methods, a support vector machine (SVM) classifier yielded classification accuracy and positive predictive values of 78% and 86% with kinetic texture features compared to 78% and 73% with morphological features and 72% and 83% with textural features, respectively.

Paper Details

Date Published: 17 March 2008
PDF: 12 pages
Proc. SPIE 6915, Medical Imaging 2008: Computer-Aided Diagnosis, 69152C (17 March 2008); doi: 10.1117/12.770920
Show Author Affiliations
Shannon C. Agner, Rutgers Univ. (United States)
Salil Soman, Robert Wood Johnson Medical School (United States)
Edward Libfeld, Robert Wood Johnson Medical School (United States)
Margie McDonald, Robert Wood Johnson Medical School (United States)
Mark A. Rosen, Univ. of Pennsylvania (United States)
Mitchell D. Schnall, Univ. of Pennsylvania (United States)
Deanna Chin, Robert Wood Johnson Medical School (United States)
John Nosher, Robert Wood Johnson Medical School (United States)
Anant Madabhushi, Rutgers Univ. (United States)

Published in SPIE Proceedings Vol. 6915:
Medical Imaging 2008: Computer-Aided Diagnosis
Maryellen L. Giger; Nico Karssemeijer, Editor(s)

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